Who Created Methamphetamine: Explore The Origins

Clinically Reviewed
A formal portrait of The Haven Detox clinical director, Dr. Ignatov

Dr. Rostislav Ignatov, MD

Chief Medical Officer

Introduction To Methamphetamine

Methamphetamine, often called meth, is a powerful drug that affects the brain and body. It comes in several forms, including a white powder or crystalline form. People usually take meth by snorting, smoking, or injecting it. Meth is known for giving a quick, intense feeling of euphoria or a “rush.” It also commonly goes by names like crystal meth, speed, ice, and glass.

Using meth can lead to serious health problems. It can increase heart rate, blood pressure, and body temperature. Long-term use can damage the brain, leading to memory loss and violent behavior. In addition, meth use can cause severe dental issues, known as “meth mouth,” and extreme weight loss.

Methamphetamine is highly addictive, meaning users can develop a strong dependence on it.Treatment for meth addiction often requires medical help and support from family members and friends. It is essential to seek help if you or someone you know is struggling with meth addiction.
 

Who invented Methamphetamine?

 

Discovery of Amphetamine

In 1887, Romanian chemist Lazăr Edeleanu first synthesized amphetamine in Germany. He named the compound phenylisopropylamine. Although Edeleanu’s discovery initially garnered little attention, it laid the essential groundwork for future developments in stimulant research. Scientists would later recognize amphetamine’s stimulating effects on the central nervous system, paving the way for both medical applications and recreational use.

 

Nagai Nagayoshi: The pioneer of Methamphetamine

The invention of methamphetamine itself is credited to Nagai Nagayoshi, a Japanese chemist. In 1893, he became the first to synthesize methamphetamine by extracting and modifying ephedrine, a natural stimulant found in certain plants. Nagayoshi’s work was groundbreaking and marked a significant turning point in pharmaceutical chemistry. His synthesis demonstrated the potential of creating powerful synthetic stimulants from naturally occurring substances, influencing both medicine and society for decades to come.

 

Other Notable Contributors

Several other scientists made important contributions to methamphetamine’s history. In 1919, Japanese pharmacologist Akira Ogata improved Nagai’s synthesis method, making meth easier to produce. During World War II, the drug gained popularity as a stimulant for soldiers for its ability to combat fatigue. Notable figures like Dr. Gordon Alles and Dr. Fritz Hauschild also contributed to the study and development of this powerful drug.

 

Key Takeaways

Methamphetamine was first synthesized in the late 19th century, setting the stage for its later developments. This article covers:

  • During World War II, meth was used by military forces to enhance performance, leading to its widespread use and later abuse.
  • Illegal meth production surged with the rise of underground labs and criminal organizations, leading to its global spread.
  • Today, methamphetamine is an illicit drug, and its production methods are more sophisticated, posing serious challenges.

Methamphetamine was given to soldiers during WWII to boost their energy, endurance, and alertness.

 

World War II And Methamphetamine

Methamphetamine played a significant role during World War II, influencing both military strategy and post-war society. Its use by various military forces and its aftermath reveal the profound impact of this powerful stimulant.

 

German Military Use

During World War II, the German military used methamphetamine extensively. Known as “Pervitin,” it was given to soldiers to boost their energy, endurance, and alertness. This drug enabled troops to stay awake for extended periods, enhancing their combat effectiveness. The widespread use of methamphetamine among German soldiers highlighted its potential to enhance performance despite the severe side effects that many experienced.

 

Japanese Military Use

The Japanese military also made extensive use of methamphetamine during World War II. The drug was distributed under the brand name Philopon. Japanese soldiers used it to stay awake and fight fatigue, similar to the German experience. Methamphetamine helped the Japanese military maintain their combat effectiveness in challenging conditions, particularly in the Pacific Theater, where long and grueling engagements were common.

 

Post-War Proliferation

After the war, the use of methamphetamine spread beyond the military. Soldiers returning home brought knowledge of the drug with them, leading to its increased availability and abuse in civilian populations. In the post-war years, methamphetamine was marketed for various medical conditions, further increasing its use. However, the adverse effects became apparent, leading to tighter regulations and eventual bans in many countries.

 

Methamphetamine Evolution And Impact

 

Medical Origins

Originally introduced in the 1950s as a prescription drug for conditions like ADHD and obesity, methamphetamine gained popularity for its stimulant effects. Promoted by pharmaceutical companies under names like Desoxyn, it was widely prescribed until its addictive potential became clear. By the 1970s, mounting health concerns led to stricter legal controls and classification as a controlled substance, limiting its legitimate use and prompting a shift toward illegal production.

 

Illicit Production

As legal restrictions tightened, underground meth labs emerged, using hazardous chemicals and unsupervised methods to meet growing demand. Criminal organizations quickly capitalized on this shift, establishing extensive networks for manufacturing and distributing methamphetamine. Over time, illicit production spread globally, adapting to enforcement efforts and creating a widespread public health issue fueled by international trafficking and organized crime.

 

Modern Consequences

Today, methamphetamine remains a serious threat, classified as a Schedule II controlled substance due to its high abuse potential. While production methods have grown more advanced—often involving pseudoephedrine from cold medications—the drug continues to devastate users with physical and mental health issues. Its social impact is equally severe, contributing to crime, broken families, and economic hardship, necessitating ongoing efforts in prevention, treatment, and law enforcement.

Updated
November 13, 2025

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