What is methadone?

Clinically Reviewed
Dr. Ignatov, Medical Director at The Haven Detox
Chief Medical Officer​​

Methadone is a synthetic opioid medication that is used to treat opioid use disorder. Along with buprenorphine and naltrexone, it is one of the most common prescription drugs approved for opioid addiction.

Methadone is highly effective, especially when combined with counseling, behavioral therapy, support groups, and recovery coaching.

Table of Contents

What is methadone used for?

Methadone treats opioid use disorder in two ways:

  • Alleviates uncomfortable opioid withdrawal symptoms
  • Satisfies opioid cravings and eases obsessive thoughts about getting high

This combination of effects helps you to focus on your recovery while you are in treatment, rather than on the physical and psychological effects of addiction. It also makes it more likely for those with an opioid addiction to accept help because it relieves some of the fear around painful withdrawals and obsessive cravings.

Because it is a powerful prescription opioid with pain-relieving properties, Methadone is also used to treat long-term, chronic pain from conditions like cancer.


How is methadone used to treat opiate withdrawal?

Methadone can be used to treat opioid addiction:

  • In the long term, as part of a methadone maintenance program
  • In the short term, to help with opioid detox (this is less common)

However, when it comes to treating opioid withdrawal with inpatient detox, doctors usually prefer other medications like suboxone. Methadone is almost always used in a long-term, maintenance setting.

 

What is methadone maintenance treatment?

Methadone is prescribed for opiate use disorder as part of a maintenance program. In methadone maintenance, you go to a dedicated treatment facility every day to take your daily dose of medication while being supervised by nursing staff. It’s not just substituting one drug for another; the point is to satisfy the opioid receptors in the brain without the individual having to use illicit street drugs.

Methadone maintenance is a long-term commitment that is typically reserved for those who do not respond well to other medications or have repeatedly tried other medications and treatments unsuccessfully.

Unlike other typical prescriptions, where you can take your medicine at home, Methadone is dispensed to patients at an Opioid Treatment Program to ensure precise dosing and medical supervision. This reduces the risk of people double-dosing or being inconsistent with treatment.

People who are prescribed methadone can only take home their prescription after a period of successful treatment, at the discretion of their doctor.

 

When is methadone used for opioid addiction?

Methadone is prescribed to treat opioid use disorder, but it’s less common than newer medications for opioid treatment, like Suboxone. This is because Methadone lacks several important advantages that Suboxone has, like:

  • The Ceiling Effect – The ceiling effect means that the opioid effects level off at a certain point, meaning it doesn’t get you high. Conversely, methadone is a full opioid that works similarly to oxycodone or morphine, so it lacks this built-in safety measure.
  • Convenient Administration – Methadone requires traveling to an OTP Opioid Treatment Program to receive your dose. Suboxone, like other prescriptions, can be filled at a pharmacy and taken at home.
  • Lower Overdose Risk – Buprenorphine is less likely to cause respiratory depression compared to methadone.

Despite the disadvantages, there are times when Methadone treatment makes more sense, for example:

  • Example 1 – Other MAT options, such as buprenorphine, aren’t adequately controlling cravings, and the individual has continued to relapse despite several attempts at treatment.
  • Example 2 – When someone has been taking methadone for a long time and has had continued success, it doesn’t always make sense to risk relapse by switching to another medication. That said, many people transition from methadone to buprenorphine successfully.
  • Example 3 – They live in a high-risk environment that is not supportive of their recovery or where contact with opioids is likely.

No one medication or treatment is better; it just depends on the individual and their specific needs.


How does methadone actually work?

Methadone works by activating the same opioid receptors in your brain as drugs like heroin, fentanyl, or oxycodone, but in a much safer and controlled way under the supervision of a doctor.


Activation of these Mu-opioid receptors helps control opioid cravings and alleviate withdrawal symptoms, allowing individuals to function normally without the cycle of repeated opioid use needed to avoid withdrawal. This combined effect plays a critical role in supporting long-term recovery from opioid use disorder.

For many people, Methadone is a life-saver because they can maintain a job, spend time with loved ones, and live a normal life without having to fuel their addiction.

 

How long do you take methadone for?

The minimum recommended length of time for methadone treatment is 1 year. This is because stopping methadone requires a slow, gradual tapering off process to minimize withdrawal symptoms.

Some people take methadone for a year and then immediately start tapering off, while others choose to stay on methadone treatment for years. It depends on the individual and their plan for treatment.

The most important thing is that you don’t stop taking methadone abruptly or try to go cold turkey by yourself because it can cause harmful withdrawal. A licensed drug and alcohol treatment center that specializes in detox can help you safely taper off of methadone, even if you have been taking it without a prescription.


Does methadone get you high?

No, methadone does not cause a euphoric “high” feeling when it is dosed appropriately. It’s more about what you won’t feel – uncomfortable detox symptoms and heavy cravings to use drugs.

 

What does detox with methadone feel like?

Methadone treatment doesn’t feel like much of anything. The medication starts relieving opioid withdrawal symptoms within the first 30 minutes to an hour, and the effects should last until it’s time for your next dose.

Your medical team will work with you to find a dose that doesn’t make you feel high, but still gives you relief and allows you to function.

 

What is the average dose of methadone?

Every patient is different, and opioid tolerance can vary widely from person to person. That said, there are some general guidelines for methadone dosing:

  • The idea is to start with a low dose, and then it is gradually increased until the maintenance dose is reached.
  • The first dose is typically between 10-30 mgs. Those who recently used opioids, or who used stronger opioids like fentanyl, will need the higher end of this range.
  • After that, doses can be increased by 5-10 mgs every three days.
  • Do not increase the dose by more than 20 mgs per week.
  • Most people stabilize somewhere between 40 and 120 mgs per day.

What does a dose of methadone look like?

Methadone comes in tablet, wafer, or liquid form, depending on the manufacturer.


 

Are there any side effects of taking methadone?

Yes, like any medication, methadone can cause side effects. The short-term side effects of methadone are very similar to those of other opioids and commonly include:

  • Drowsiness, sleepiness
  • Confusion, dazed feeling
  • Itchiness
  • Constipation
  • Nausea & vomiting

Typically, these side effects are manageable and go away after the body builds up a tolerance. If you are experiencing side effects from methadone that aren’t going away, you should talk to your medical team, as your dose may need to be adjusted.

Taking methadone in the long-term causes you to build up a tolerance and potentially physical dependence. However, targeted, controlled dosing of a medication under a doctor’s supervision is not the same as living in addiction. Many patients on methadone treatment live happy and successful lives.


Is methadone addictive?

When taken as prescribed, Methadone is a safe and effective treatment for opioid use disorder.
While it does cause physical dependence, it is not as addictive as street drugs like fentanyl or heroin because of the dosage and how it’s administered.

Also, taking methadone is not just substituting one addiction for another. Methadone, like suboxone and naltrexone, is specifically designed to reduce cravings, alleviate withdrawal symptoms, and overall make you feel better so that you can focus on treatment and getting healthy.

 

How long does it take to detox from methadone?

Methadone has a longer half-life than other opioids, which means it stays in the body for longer. It also means symptoms often last longer than fentanyl or heroin withdrawal, especially if you have been taking a high dose for a long time.

Methadone Withdrawal Timeline

  • Initial withdrawal symptoms kick in about 24-48 hours after the last dose and can last anywhere from two weeks to a month.
  • Peak symptoms appear after a few days to a week, gradually improving over the course of several weeks
  • The most intense symptoms last for one or two weeks
  • Post Acute Withdrawal Syndrome (PAWS) from methadone can last a lot longer, with some symptoms, like memory fog and sleep difficulties, lasting for several months after the last dose.

 

What does withdrawal from methadone feel like?

Withdrawal from methadone is very similar to that of other opioids. The main difference is that symptoms tend to last longer because methadone stays in your system longer than other opioid medications.

Symptoms come in waves and can range from feeling slightly uncomfortable to full physical withdrawal symptoms, where seeking medical support is vital.

What are the most common Methadone detox symptoms?

The most common withdrawal symptoms when detoxing from methadone are:

  • Sleep issues – insomnia at night, sleepiness during the day.
  • Anxiety & restlessness – feeling agitated
  • Stomach problems – nausea, vomiting, general queasiness
  • Runny nose
  • Opioid cravings
  • Cold sweats

Can you overdose on methadone?

Like any opioid, if you take enough methadone, you can overdose. However, the fact that it is administered under the care of a doctor makes the risk of overdosing during methadone maintenance treatment extremely rare.

It’s also important to note that one of the most important benefits of methadone treatment is that it significantly reduces the risk of overdose death. People who take methadone are less likely to use illicit opioids such as fentanyl or heroin, which can vary widely in potency and may contain dangerous contaminants.


Does insurance cover methadone treatment?

Yes, methadone treatment is covered under most major insurance plans, as well as Medicaid. However, coverage may vary, and there may be out-of-pocket costs depending on your plan and whether the provider is in network.

The medication itself isn’t expensive, but a large majority of the cost of methadone treatment goes to therapy and administrative costs. Typically, if you are prescribed methadone, you are an active patient at an outpatient or inpatient addiction treatment center.

Medically supervised detox is also covered by most insurance plans. If you are struggling with opioid addiction, it is important that you speak to a medical provider. The best way to begin your path to recovery is at a 24/7, medically supervised detox center that is Joint Commission Gold Seal accredited.

 

Sources

Updated
June 24, 2026

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